Studies in rodents and humans demonstrate that CCR5 manipulations enhance memory and recovery after brain injury!

ollaborative studies (PDF) between the Carmichael and Silva Laboratories at UCLA showed that manipulations that decreased CCR5, which the Silva lab previously showed enhanced memory, were also shown to enhance recovery after stroke and traumatic brain injury (studies with the Shohami lab). Collaborative studies in humans (Bornstein lab) were consistent with these results in rodents, since individuals with a naturally occurring CCR5 null mutation (Delta 32 allele) were also shown to have better motor and cognitive recovery after stroke (PDF)!

Key Publications:

Mary T. Joy, Einor Ben Assayag, Dalia Shabashov-Stone, Sigal Liraz-Zaltsman, Nikita S. Thareja,Marcela Arenas, Efrat Kliper, Amos D. Korczyn, Efrat L. Kesner, Miou Zho, Shan Huang2, Tawnie K. Silva2, Noomi, Katz, Natan M. Bornstein, Alcino J. Silva, Esther Shohami, Stanley T. Carmichael. CCR5 is a therapeutic target to stimulate recovery in stroke and traumatic brain injury. Cell (in press)(PDF)
Miou Zhou Stuart Greenhill Shan Huang Tawnie K Silva Yoshitake Sano Shumin Wu Ying Cai Yoshiko Nagaoka Megha Sehgal Denise J Cai Yong-Seok Lee Kevin Fox Alcino J Silva. CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory. DOI:; Published December 20, 2016; Cite as eLife 2016;10.7554/eLife.209851. (PDF)