cell biology of learning and memory

David Glanzman

David Glanzman's laboratory is interested in the cell biology of learning and memory in simple organisms. Their research uses two animals, the marine snail Aplysia californica, and the zebrafish (Danio rerio). They are using electrophysiological, genetic, and imaging techniques to analyze the mechanisms of habituation and sensitization of the startle reflex.

Website: http://www.ibp.ucla.edu/physcifacultyindiv.php?FacultyKey=21

Recent Publications

Chen, S., Cai, D., Pearce, K., Sun, P. Y., Roberts, A. C. & Glanzman, D. L.. 2014. Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia. Elife 3: e03896. doi: 10.7554/eLife.03896. http://www.ncbi.nlm.nih.gov/pubmed/25402831

Cai, D., Pearce, K., Chen, S. & Glanzman, D. L.. 2012. Reconsolidation of long-term memory in Aplysia. Current Biology 22: 1783-1788. doi: 10.1016/j.cub.2012.07.038. http://www.sciencedirect.com/science/article/pii/S0960982212008639

Protein kinase m maintains long-term sensitization and long-term facilitation in Aplysia. Cai, D., Pearce, K., Chen, S. and Glanzman, D. L. J. Neurosci. 31 (17): 6421-6431 (2011)

Long-term habituation of the gill-withdrawal reflex in Aplysia requires gene transcription, calcineurin and L-type voltage-gated calcium channels. Esdin, Pearce, K. and Glanzman, D. L. Frontiers Behav. Neurosci. (2010)

Common mechanisms of synaptic plasticity in vertebrates and invertebrates. Glanzman, D. L. Curr. Biol. 20 : R31-R36 (2010)

Ion pumps get more glamorous. Glanzman, D.L. Nat. Neurosci. 13 : 4-5 (2010)

Role of protein kinase C in the induction and maintenance of serotonin-dependent enhancement of the glutamate response in isolated siphon motor neurons of Aplysia californica Villareal, G. V., Li, Q., Cai, D., Fink, A. E., Lim, T., Bougie, J. K., Sossin, W. S., and Glanzman, D. L. J. Neurosci. 29 (16): 5100-5107 (2009)